AustralieFrV1, Main, Exploration, bibRecord, 002146

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations

Identifieur interne : 002146 ( Main/Exploration ); précédent : 002145; suivant : 002147

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations

Auteurs : Gordon Fehringer [Canada] ; Peter Kraft ; Paul D. Pharoah [Royaume-Uni] ; Rosalind A. Eeles [Royaume-Uni] ; Nilanjan Chatterjee [États-Unis] ; Fred Schumacher [États-Unis] ; Joellen Schildkraut [États-Unis] ; Sara Lindström ; Paul Brennan [France] ; Heike Bickeböller [Allemagne] ; Richard S. Houlston [Royaume-Uni] ; Maria Teresa Landi [États-Unis] ; Neil Caporaso [États-Unis] ; Angela Risch [Autriche, Allemagne] ; Ali Amin Al Olama [Royaume-Uni] ; Sonja I. Berndt [États-Unis] ; Edward Giovannucci ; Henrik Grönberg [Suède] ; Zsofia Kote-Jarai [Royaume-Uni] ; Jing Ma ; Kenneth Muir [Royaume-Uni] ; Meir Stampfer ; Victoria L. Stevens ; Fredrik Wiklund [Suède] ; Walter Willett ; Ellen L. Goode ; Jennifer Permuth [États-Unis] ; Harvey A. Risch [États-Unis] ; Brett M. Reid [États-Unis] ; Stephane Bezieau [France] ; Hermann Brenner [Allemagne] ; Andrew T. Chan [États-Unis] ; Jenny Chang-Claude [Allemagne] ; Thomas J. Hudson ; Jonathan K. Kocarnik [États-Unis] ; Polly A. Newcomb [États-Unis] ; Robert E. Schoen [États-Unis] ; Martha L. Slattery [États-Unis] ; Emily White [États-Unis] ; Muriel A. Adank [Pays-Bas] ; Habibul Ahsan [États-Unis] ; Kristiina Aittom Ki [Finlande] ; Laura Baglietto [Australie] ; Carl Blomquist [Finlande] ; Federico Canzian [Allemagne] ; Kamila Czene [Suède] ; Isabel Dos-Santos-Silva [Royaume-Uni] ; A. Heather Eliassen ; Jonine Figueroa [États-Unis] ; Dieter Flesch-Janys ; Olivia Fletcher [Royaume-Uni] ; Montserrat Garcia-Closas [États-Unis] ; Mia M. Gaudet ; Nichola Johnson [Royaume-Uni] ; Per Hall [Suède] ; Aditi Hazra ; Rebecca Hein [Allemagne] ; Albert Hofman [Pays-Bas] ; John L. Hopper [Australie] ; Astrid Irwanto [Singapour] ; Mattias Johansson [France] ; Rudolf Kaaks [Allemagne] ; Muhammad G. Kibriya [États-Unis] ; Peter Lichtner [Allemagne] ; Jianjun Liu [Singapour] ; Eiliv Lund [Norvège] ; Enes Makalic [Australie] ; Alfons Meindl [Allemagne] ; Bertram Müller-Myhsok [Allemagne] ; Taru A. Muranen [Finlande] ; Heli Nevanlinna [Finlande] ; Petra H. Peeters ; Julian Peto [Royaume-Uni] ; Ross L. Prentice [États-Unis] ; Nazneen Rahman [Royaume-Uni] ; Maria Jose Sanchez [Espagne] ; Daniel F. Schmidt [Australie] ; Rita K. Schmutzler [Allemagne] ; Melissa C. Southey [Australie] ; Rulla Tamimi ; Ruth C. Travis [Royaume-Uni] ; Clare Turnbull [Royaume-Uni] ; Andre G. Uitterlinden [Pays-Bas] ; Zhaoming Wang [États-Unis] ; Alice S. Whittemore [États-Unis] ; Xiaohong R. Yang [États-Unis] ; Wei Zheng [États-Unis] ; Thorunn Rafnar [Islande] ; Julius Gudmundsson [Islande] ; Simon N. Stacey [Islande] ; Kari Stefansson [Islande] ; Patrick Sulem [Islande] ; Y. Ann Chen [États-Unis] ; Jonathan P. Tyrer [Royaume-Uni] ; David C. Christiani ; Yongyue Wei ; Hongbing Shen [République populaire de Chine] ; Zhibin Hu [République populaire de Chine] ; Xiao-Ou Shu [États-Unis] ; Kouya Shiraishi [Japon] ; Atsushi Takahashi [Japon] ; Yohan Bossé [Canada] ; Ma N Obeidat [Canada] ; David Nickle [États-Unis] ; Wim Timens [Pays-Bas] ; Matthew L. Freedman [États-Unis] ; Qiyuan Li ; Daniela Seminara [États-Unis] ; Stephen J. Chanock [États-Unis] ; Jian Gong [États-Unis] ; Ulrike Peters [États-Unis] ; Stephen B. Gruber [États-Unis] ; Christopher I. Amos [Liban] ; Thomas A. Sellers [États-Unis] ; Douglas F. Easton [Royaume-Uni] ; David J. Hunter ; Christopher A. Haiman [États-Unis] ; Brian E. Henderson [États-Unis] ; Rayjean J. Hung [Canada]

Source :

Cancer research [ 0008-5472 ] ; 2016.

RBID : PMC:5010493

Descripteurs français

KwdFr :
- Femelle, Génotype, Humains, Mâle, Tumeurs colorectales (génétique), Tumeurs de l'ovaire (génétique), Tumeurs de la prostate (génétique), Tumeurs du poumon (génétique), Tumeurs du sein (génétique), Étude d'association pangénomique.
MESH :
- génétique : Tumeurs colorectales, Tumeurs de l'ovaire, Tumeurs de la prostate, Tumeurs du poumon, Tumeurs du sein.
- Femelle, Génotype, Humains, Mâle, Étude d'association pangénomique.

English descriptors

KwdEn :
- Breast Neoplasms (genetics), Colorectal Neoplasms (genetics), Female, Genome-Wide Association Study, Genotype, Humans, Lung Neoplasms (genetics), Male, Ovarian Neoplasms (genetics), Prostatic Neoplasms (genetics).
MESH :
- genetics : Breast Neoplasms, Colorectal Neoplasms, Lung Neoplasms, Ovarian Neoplasms, Prostatic Neoplasms.
- Female, Genome-Wide Association Study, Genotype, Humans, Male.

Abstract

Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with ADAM15/THBS3 gene expression in lung. We also identified a known breast cancer locus CASP8/ALS2CR12 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast BRCA2 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5010493

DOI: 10.1158/0008-5472.CAN-15-2980
PubMed: 27197191
PubMed Central: 5010493

Affiliations:

Le document en format XML

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<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
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<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
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<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
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<author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
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<author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name>
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<author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name>
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<author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name>
<affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name>
<affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff>
<wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name>
<affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name>
<affiliation wicri:level="2"><nlm:aff id="A31">University of Utah Health Sciences Center, Salt Lake City, Utah, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name>
<affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name>
<affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff>
<wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name>
<affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff>
<wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
<affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff>
<wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name>
<affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name>
<affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea>
<wicri:noRegion>Tromso</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff>
<wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea>
<wicri:noRegion>Sutton</wicri:noRegion>
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<author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name>
<affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea>
<wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford</wicri:regionArea>
<placeName><settlement type="city">Oxford</settlement>
<region type="country">Angleterre</region>
<region type="comté" nuts="2">Oxfordshire</region>
<settlement type="city">Oxford</settlement>
</placeName>
<orgName type="university">Université d'Oxford</orgName>
</affiliation>
</author>
<author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea>
<wicri:noRegion>Sutton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
<wicri:noRegion>Tampa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name>
<affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name>
<affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name>
<affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name>
<affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea>
<wicri:noRegion>Yokohama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name>
<affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name>
<affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea>
<wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name>
<affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name>
<affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name>
<affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name>
<affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff>
<wicri:noCountry code="subfield">Xiamen China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name>
<affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea>
<wicri:noRegion>Dartmouth College</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
<wicri:noRegion>Tampa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations</title>
<author><name sortKey="Fehringer, Gordon" sort="Fehringer, Gordon" uniqKey="Fehringer G" first="Gordon" last="Fehringer">Gordon Fehringer</name>
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<author><name sortKey="Kraft, Peter" sort="Kraft, Peter" uniqKey="Kraft P" first="Peter" last="Kraft">Peter Kraft</name>
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<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
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<wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
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<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
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<author><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
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<author><name sortKey="Schumacher, Fred" sort="Schumacher, Fred" uniqKey="Schumacher F" first="Fred" last="Schumacher">Fred Schumacher</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
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<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Schildkraut, Joellen" sort="Schildkraut, Joellen" uniqKey="Schildkraut J" first="Joellen" last="Schildkraut">Joellen Schildkraut</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Virginia, Charlottesville</wicri:regionArea>
<wicri:noRegion>Charlottesville</wicri:noRegion>
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<author><name sortKey="Lindstrom, Sara" sort="Lindstrom, Sara" uniqKey="Lindstrom S" first="Sara" last="Lindström">Sara Lindström</name>
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<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
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<author><name sortKey="Brennan, Paul" sort="Brennan, Paul" uniqKey="Brennan P" first="Paul" last="Brennan">Paul Brennan</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
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<settlement type="city">Lyon</settlement>
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</affiliation>
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<author><name sortKey="Bickeboller, Heike" sort="Bickeboller, Heike" uniqKey="Bickeboller H" first="Heike" last="Bickeböller">Heike Bickeböller</name>
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<wicri:regionArea>University of Göttingen, Medical School, Göttingen</wicri:regionArea>
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<settlement type="city">Göttingen</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Houlston, Richard S" sort="Houlston, Richard S" uniqKey="Houlston R" first="Richard S." last="Houlston">Richard S. Houlston</name>
<affiliation wicri:level="3"><nlm:aff id="A4">Institute of Cancer Research, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Landi, Maria Teresa" sort="Landi, Maria Teresa" uniqKey="Landi M" first="Maria Teresa" last="Landi">Maria Teresa Landi</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Risch, Angela" sort="Risch, Angela" uniqKey="Risch A" first="Angela" last="Risch">Angela Risch</name>
<affiliation wicri:level="1"><nlm:aff id="A10">Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg, Austria</nlm:aff>
<country xml:lang="fr">Autriche</country>
<wicri:regionArea>Division of Cancer Genetics/Epigenetics, Department of Molecular Biology, University of Salzburg, Salzburg</wicri:regionArea>
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<affiliation wicri:level="3"><nlm:aff id="A11">Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Epigenomics and Cancer Risk Factors, DKFZ – German Cancer Research Center, Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A12">Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Translational Lung Research Center Heidelberg (TLRC-H), Member of the German Center for Lung Research (DZL), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Olama, Ali Amin Al" sort="Olama, Ali Amin Al" uniqKey="Olama A" first="Ali Amin Al" last="Olama">Ali Amin Al Olama</name>
<affiliation wicri:level="1"><nlm:aff id="A13">Cambridge University, Cambridge, United Kingdom</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Cambridge University, Cambridge</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Giovannucci, Edward" sort="Giovannucci, Edward" uniqKey="Giovannucci E" first="Edward" last="Giovannucci">Edward Giovannucci</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gronberg, Henrik" sort="Gronberg, Henrik" uniqKey="Gronberg H" first="Henrik" last="Grönberg">Henrik Grönberg</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kote Jarai, Zsofia" sort="Kote Jarai, Zsofia" uniqKey="Kote Jarai Z" first="Zsofia" last="Kote-Jarai">Zsofia Kote-Jarai</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ma, Jing" sort="Ma, Jing" uniqKey="Ma J" first="Jing" last="Ma">Jing Ma</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
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<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Manchester, Manchester</wicri:regionArea>
<placeName><settlement type="city">Manchester</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Manchester</region>
<settlement type="city">Manchester</settlement>
</placeName>
<orgName type="university">Université de Manchester</orgName>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A17">The University of Warwick, Coventry, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>The University of Warwick, Coventry</wicri:regionArea>
<wicri:noRegion>Coventry</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stampfer, Meir" sort="Stampfer, Meir" uniqKey="Stampfer M" first="Meir" last="Stampfer">Meir Stampfer</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Stevens, Victoria L" sort="Stevens, Victoria L" uniqKey="Stevens V" first="Victoria L." last="Stevens">Victoria L. Stevens</name>
<affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff>
<wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wiklund, Fredrik" sort="Wiklund, Fredrik" uniqKey="Wiklund F" first="Fredrik" last="Wiklund">Fredrik Wiklund</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Willett, Walter" sort="Willett, Walter" uniqKey="Willett W" first="Walter" last="Willett">Walter Willett</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
<affiliation><nlm:aff id="A19">Mayo Clinic, Rochester Minnesota</nlm:aff>
<wicri:noCountry code="subfield">Rochester Minnesota</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Permuth, Jennifer" sort="Permuth, Jennifer" uniqKey="Permuth J" first="Jennifer" last="Permuth">Jennifer Permuth</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
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</affiliation>
</author>
<author><name sortKey="Risch, Harvey A" sort="Risch, Harvey A" uniqKey="Risch H" first="Harvey A." last="Risch">Harvey A. Risch</name>
<affiliation wicri:level="2"><nlm:aff id="A21">Yale School of Public Health, New Haven, Connecticut, USA</nlm:aff>
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<wicri:regionArea>Yale School of Public Health, New Haven, Connecticut</wicri:regionArea>
<placeName><region type="state">Connecticut</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Reid, Brett M" sort="Reid, Brett M" uniqKey="Reid B" first="Brett M." last="Reid">Brett M. Reid</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
<wicri:noRegion>Tampa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bezieau, Stephane" sort="Bezieau, Stephane" uniqKey="Bezieau S" first="Stephane" last="Bezieau">Stephane Bezieau</name>
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<country xml:lang="fr">France</country>
<wicri:regionArea>Service de Génétique Médicale, Nantes</wicri:regionArea>
<placeName><region type="region">Pays de la Loire</region>
<region type="old region">Pays de la Loire</region>
<settlement type="city">Nantes</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
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<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A24">Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Preventive Oncology, German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A25">German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name>
<affiliation wicri:level="3"><nlm:aff id="A26">Massachusetts General Hospital, Boston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Massachusetts General Hospital, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Chang Claude, Jenny" sort="Chang Claude, Jenny" uniqKey="Chang Claude J" first="Jenny" last="Chang-Claude">Jenny Chang-Claude</name>
<affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name>
<affiliation><nlm:aff id="A28">Ontario Institute for Cancer Research, Toronto Ontario</nlm:aff>
<wicri:noCountry code="subfield">Toronto Ontario</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kocarnik, Jonathan K" sort="Kocarnik, Jonathan K" uniqKey="Kocarnik J" first="Jonathan K." last="Kocarnik">Jonathan K. Kocarnik</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newcomb, Polly A" sort="Newcomb, Polly A" uniqKey="Newcomb P" first="Polly A." last="Newcomb">Polly A. Newcomb</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Schoen, Robert E" sort="Schoen, Robert E" uniqKey="Schoen R" first="Robert E." last="Schoen">Robert E. Schoen</name>
<affiliation wicri:level="3"><nlm:aff id="A30">University of Pittsburgh Medical Center, Pittsburgh, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Pittsburgh Medical Center, Pittsburgh</wicri:regionArea>
<placeName><settlement type="city">Pittsburgh</settlement>
<region type="state">Pennsylvanie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Slattery, Martha L" sort="Slattery, Martha L" uniqKey="Slattery M" first="Martha L." last="Slattery">Martha L. Slattery</name>
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<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Utah Health Sciences Center, Salt Lake City, Utah</wicri:regionArea>
<placeName><region type="state">Utah</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="White, Emily" sort="White, Emily" uniqKey="White E" first="Emily" last="White">Emily White</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Adank, Muriel A" sort="Adank, Muriel A" uniqKey="Adank M" first="Muriel A." last="Adank">Muriel A. Adank</name>
<affiliation wicri:level="3"><nlm:aff id="A32">VU University Medical Center, Amsterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>VU University Medical Center, Amsterdam</wicri:regionArea>
<placeName><settlement type="city">Amsterdam</settlement>
<region nuts="2" type="province">Hollande-Septentrionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name>
<affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Aittom Ki, Kristiina" sort="Aittom Ki, Kristiina" uniqKey="Aittom Ki K" first="Kristiina" last="Aittom Ki">Kristiina Aittom Ki</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Baglietto, Laura" sort="Baglietto, Laura" uniqKey="Baglietto L" first="Laura" last="Baglietto">Laura Baglietto</name>
<affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Blomquist, Carl" sort="Blomquist, Carl" uniqKey="Blomquist C" first="Carl" last="Blomquist">Carl Blomquist</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Canzian, Federico" sort="Canzian, Federico" uniqKey="Canzian F" first="Federico" last="Canzian">Federico Canzian</name>
<affiliation wicri:level="1"><nlm:aff id="A36">Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Genomic Epidemiology Group, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Czene, Kamila" sort="Czene, Kamila" uniqKey="Czene K" first="Kamila" last="Czene">Kamila Czene</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Dos Santos Silva, Isabel" sort="Dos Santos Silva, Isabel" uniqKey="Dos Santos Silva I" first="Isabel" last="Dos-Santos-Silva">Isabel Dos-Santos-Silva</name>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Eliassen, A Heather" sort="Eliassen, A Heather" uniqKey="Eliassen A" first="A. Heather" last="Eliassen">A. Heather Eliassen</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Flesch Janys, Dieter" sort="Flesch Janys, Dieter" uniqKey="Flesch Janys D" first="Dieter" last="Flesch-Janys">Dieter Flesch-Janys</name>
<affiliation><nlm:aff id="A38">University Medical Center Hamburg-Eppendorf, Hamburg Germany</nlm:aff>
<wicri:noCountry code="subfield">Hamburg Germany</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Fletcher, Olivia" sort="Fletcher, Olivia" uniqKey="Fletcher O" first="Olivia" last="Fletcher">Olivia Fletcher</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gaudet, Mia M" sort="Gaudet, Mia M" uniqKey="Gaudet M" first="Mia M." last="Gaudet">Mia M. Gaudet</name>
<affiliation><nlm:aff id="A18">Epidemiology Research Program, American Cancer Society, Atlanta GA</nlm:aff>
<wicri:noCountry code="subfield">Atlanta GA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Johnson, Nichola" sort="Johnson, Nichola" uniqKey="Johnson N" first="Nichola" last="Johnson">Nichola Johnson</name>
<affiliation wicri:level="3"><nlm:aff id="A39">Breakthrough Research Centre, The Institute of Cancer Research, London, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Breakthrough Research Centre, The Institute of Cancer Research, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hall, Per" sort="Hall, Per" uniqKey="Hall P" first="Per" last="Hall">Per Hall</name>
<affiliation wicri:level="3"><nlm:aff id="A14">Karolinska Institutet, Stockholm, Sweden</nlm:aff>
<country xml:lang="fr">Suède</country>
<wicri:regionArea>Karolinska Institutet, Stockholm</wicri:regionArea>
<placeName><settlement type="city">Stockholm</settlement>
<region nuts="2">Svealand</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hazra, Aditi" sort="Hazra, Aditi" uniqKey="Hazra A" first="Aditi" last="Hazra">Aditi Hazra</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
<affiliation wicri:level="1"><nlm:aff id="A40">Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Division of Cancer Epidemiology, German Cancer Research Center (DKFZ) Heidelberg</wicri:regionArea>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
<wicri:noRegion>German Cancer Research Center (DKFZ) Heidelberg</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A41">Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Institute of Medical Statistics, Informatics and Epidemiology, University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hofman, Albert" sort="Hofman, Albert" uniqKey="Hofman A" first="Albert" last="Hofman">Albert Hofman</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hopper, John L" sort="Hopper, John L" uniqKey="Hopper J" first="John L." last="Hopper">John L. Hopper</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Irwanto, Astrid" sort="Irwanto, Astrid" uniqKey="Irwanto A" first="Astrid" last="Irwanto">Astrid Irwanto</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Johansson, Mattias" sort="Johansson, Mattias" uniqKey="Johansson M" first="Mattias" last="Johansson">Mattias Johansson</name>
<affiliation wicri:level="3"><nlm:aff id="A8">International Agency for Research on Cancer, Lyon, France</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea>International Agency for Research on Cancer, Lyon</wicri:regionArea>
<placeName><region type="region">Auvergne-Rhône-Alpes</region>
<region type="old region">Rhône-Alpes</region>
<settlement type="city">Lyon</settlement>
</placeName>
</affiliation>
<affiliation><nlm:aff id="A45">Department of Biobank Research, Umea University, Sweden; International Agency for Research on Cancer (IARC/WHO)</nlm:aff>
<wicri:noCountry code="subfield">Sweden; International Agency for Research on Cancer (IARC/WHO)</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Kaaks, Rudolf" sort="Kaaks, Rudolf" uniqKey="Kaaks R" first="Rudolf" last="Kaaks">Rudolf Kaaks</name>
<affiliation wicri:level="3"><nlm:aff id="A27">National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>National Center for Tumor Diseases and German Cancer Research Center (DKFZ), Heidelberg</wicri:regionArea>
<placeName><region type="land" nuts="1">Bade-Wurtemberg</region>
<region type="district" nuts="2">District de Karlsruhe</region>
<settlement type="city">Heidelberg</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Kibriya, Muhammad G" sort="Kibriya, Muhammad G" uniqKey="Kibriya M" first="Muhammad G." last="Kibriya">Muhammad G. Kibriya</name>
<affiliation wicri:level="2"><nlm:aff id="A33">University of Chicago, Chicago, IL, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Chicago, Chicago, IL</wicri:regionArea>
<placeName><region type="state">Illinois</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Lichtner, Peter" sort="Lichtner, Peter" uniqKey="Lichtner P" first="Peter" last="Lichtner">Peter Lichtner</name>
<affiliation wicri:level="1"><nlm:aff id="A46">German Research Center for Environmental Health, Neuherberg, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>German Research Center for Environmental Health, Neuherberg</wicri:regionArea>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
<wicri:noRegion>Neuherberg</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Liu, Jianjun" sort="Liu, Jianjun" uniqKey="Liu J" first="Jianjun" last="Liu">Jianjun Liu</name>
<affiliation wicri:level="1"><nlm:aff id="A44">Genome Institute of Singapore, Singapore</nlm:aff>
<country xml:lang="fr">Singapour</country>
<wicri:regionArea>Genome Institute of Singapore</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Lund, Eiliv" sort="Lund, Eiliv" uniqKey="Lund E" first="Eiliv" last="Lund">Eiliv Lund</name>
<affiliation wicri:level="1"><nlm:aff id="A47">Institute of Community Medicine, UiT The Artic University of Norway, Tromso, Norway</nlm:aff>
<country xml:lang="fr">Norvège</country>
<wicri:regionArea>Institute of Community Medicine, UiT The Artic University of Norway, Tromso</wicri:regionArea>
<wicri:noRegion>Tromso</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Makalic, Enes" sort="Makalic, Enes" uniqKey="Makalic E" first="Enes" last="Makalic">Enes Makalic</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Meindl, Alfons" sort="Meindl, Alfons" uniqKey="Meindl A" first="Alfons" last="Meindl">Alfons Meindl</name>
<affiliation wicri:level="4"><nlm:aff id="A48">Technische Universität München, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Technische Universität München, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
<settlement type="city">Munich</settlement>
</placeName>
<orgName type="university">Université technique de Munich</orgName>
</affiliation>
</author>
<author><name sortKey="Muller Myhsok, Bertram" sort="Muller Myhsok, Bertram" uniqKey="Muller Myhsok B" first="Bertram" last="Müller-Myhsok">Bertram Müller-Myhsok</name>
<affiliation wicri:level="3"><nlm:aff id="A49">Max Planck Institute of Psychiatry, Munich, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Max Planck Institute of Psychiatry, Munich</wicri:regionArea>
<placeName><region type="land" nuts="1">Bavière</region>
<region type="district" nuts="2">District de Haute-Bavière</region>
<settlement type="city">Munich</settlement>
</placeName>
</affiliation>
</author>
<author><name sortKey="Muranen, Taru A" sort="Muranen, Taru A" uniqKey="Muranen T" first="Taru A." last="Muranen">Taru A. Muranen</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nevanlinna, Heli" sort="Nevanlinna, Heli" uniqKey="Nevanlinna H" first="Heli" last="Nevanlinna">Heli Nevanlinna</name>
<affiliation wicri:level="1"><nlm:aff id="A34">University of Helsinki and Helsinki University Central Hospital, Helsinki, Finland</nlm:aff>
<country xml:lang="fr">Finlande</country>
<wicri:regionArea>University of Helsinki and Helsinki University Central Hospital, Helsinki</wicri:regionArea>
<wicri:noRegion>Helsinki</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peeters, Petra H" sort="Peeters, Petra H" uniqKey="Peeters P" first="Petra H." last="Peeters">Petra H. Peeters</name>
<affiliation><nlm:aff id="A50">Department of Epidemiology, Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht</nlm:aff>
<wicri:noCountry code="subfield">University Medical Center Utrecht</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Peto, Julian" sort="Peto, Julian" uniqKey="Peto J" first="Julian" last="Peto">Julian Peto</name>
<affiliation wicri:level="3"><nlm:aff id="A37">Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Department of Non-Communicable Disease Epidemiology, London School of Hygiene and Tropical Medicine, London</wicri:regionArea>
<placeName><settlement type="city">Londres</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Grand Londres</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Prentice, Ross L" sort="Prentice, Ross L" uniqKey="Prentice R" first="Ross L." last="Prentice">Ross L. Prentice</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rahman, Nazneen" sort="Rahman, Nazneen" uniqKey="Rahman N" first="Nazneen" last="Rahman">Nazneen Rahman</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Institute of Cancer Research, Sutton</wicri:regionArea>
<wicri:noRegion>Sutton</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name>
<affiliation wicri:level="1"><nlm:aff id="A52">Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Escuela Andaluza de Salud Publica, Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:regionArea>
<wicri:noRegion>Instituto de Investigacion Biosanitaria ibs. GRANADA</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A53">Hospitales Universitarios de Granada/Universidad de Granada, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>Hospitales Universitarios de Granada/Universidad de Granada</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="A54">CIBER de Epidemiología y Salud Pública CIBERESP, Spain</nlm:aff>
<country xml:lang="fr">Espagne</country>
<wicri:regionArea>CIBER de Epidemiología y Salud Pública CIBERESP</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Schmidt, Daniel F" sort="Schmidt, Daniel F" uniqKey="Schmidt D" first="Daniel F." last="Schmidt">Daniel F. Schmidt</name>
<affiliation wicri:level="4"><nlm:aff id="A43">Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>Melbourne School of Population Health, University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Schmutzler, Rita K" sort="Schmutzler, Rita K" uniqKey="Schmutzler R" first="Rita K." last="Schmutzler">Rita K. Schmutzler</name>
<affiliation wicri:level="1"><nlm:aff id="A55">University of Cologne, Cologne, Germany</nlm:aff>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>University of Cologne, Cologne</wicri:regionArea>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
<wicri:noRegion>Cologne</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Southey, Melissa C" sort="Southey, Melissa C" uniqKey="Southey M" first="Melissa C." last="Southey">Melissa C. Southey</name>
<affiliation wicri:level="4"><nlm:aff id="A35">The University of Melbourne, Melbourne, Victoria, Australia</nlm:aff>
<country xml:lang="fr">Australie</country>
<wicri:regionArea>The University of Melbourne, Melbourne, Victoria</wicri:regionArea>
<orgName type="university">Université de Melbourne</orgName>
<placeName><settlement type="city">Melbourne</settlement>
<region type="état">Victoria (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Tamimi, Rulla" sort="Tamimi, Rulla" uniqKey="Tamimi R" first="Rulla" last="Tamimi">Rulla Tamimi</name>
<affiliation><nlm:aff id="A15">Harvard Medical School, Boston MA; Brigham and Women’s Hospital, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Travis, Ruth C" sort="Travis, Ruth C" uniqKey="Travis R" first="Ruth C." last="Travis">Ruth C. Travis</name>
<affiliation wicri:level="4"><nlm:aff id="A56">Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK</nlm:aff>
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<orgName type="university">Université d'Oxford</orgName>
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</author>
<author><name sortKey="Turnbull, Clare" sort="Turnbull, Clare" uniqKey="Turnbull C" first="Clare" last="Turnbull">Clare Turnbull</name>
<affiliation wicri:level="1"><nlm:aff id="A51">Institute of Cancer Research, Sutton, U.K</nlm:aff>
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</author>
<author><name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
<affiliation wicri:level="3"><nlm:aff id="A42">Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands</nlm:aff>
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<wicri:regionArea>Department of Epidemiology, Erasmus Medical Center, Rotterdam</wicri:regionArea>
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</placeName>
</affiliation>
<affiliation wicri:level="3"><nlm:aff id="A58">Department of Internal Medicine, Erasmus MC, Rotterdam, The Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>Department of Internal Medicine, Erasmus MC, Rotterdam</wicri:regionArea>
<placeName><settlement type="city">Rotterdam</settlement>
<region nuts="2" type="province">Hollande-Méridionale</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Wang, Zhaoming" sort="Wang, Zhaoming" uniqKey="Wang Z" first="Zhaoming" last="Wang">Zhaoming Wang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Whittemore, Alice S" sort="Whittemore, Alice S" uniqKey="Whittemore A" first="Alice S." last="Whittemore">Alice S. Whittemore</name>
<affiliation wicri:level="2"><nlm:aff id="A57">Stanford University, Stanford, CA, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Stanford University, Stanford, CA</wicri:regionArea>
<placeName><region type="state">Californie</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Yang, Xiaohong R" sort="Yang, Xiaohong R" uniqKey="Yang X" first="Xiaohong R." last="Yang">Xiaohong R. Yang</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Zheng, Wei" sort="Zheng, Wei" uniqKey="Zheng W" first="Wei" last="Zheng">Wei Zheng</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Rafnar, Thorunn" sort="Rafnar, Thorunn" uniqKey="Rafnar T" first="Thorunn" last="Rafnar">Thorunn Rafnar</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gudmundsson, Julius" sort="Gudmundsson, Julius" uniqKey="Gudmundsson J" first="Julius" last="Gudmundsson">Julius Gudmundsson</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stacey, Simon N" sort="Stacey, Simon N" uniqKey="Stacey S" first="Simon N." last="Stacey">Simon N. Stacey</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Stefansson, Kari" sort="Stefansson, Kari" uniqKey="Stefansson K" first="Kari" last="Stefansson">Kari Stefansson</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sulem, Patrick" sort="Sulem, Patrick" uniqKey="Sulem P" first="Patrick" last="Sulem">Patrick Sulem</name>
<affiliation wicri:level="1"><nlm:aff id="A60">deCODE genetics, Amgen, Reykjavik, Iceland</nlm:aff>
<country xml:lang="fr">Islande</country>
<wicri:regionArea>deCODE genetics, Amgen, Reykjavik</wicri:regionArea>
<wicri:noRegion>Reykjavik</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
<wicri:noRegion>Tampa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name>
<affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
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</placeName>
</affiliation>
</author>
<author><name sortKey="Christiani, David C" sort="Christiani, David C" uniqKey="Christiani D" first="David C." last="Christiani">David C. Christiani</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Wei, Yongyue" sort="Wei, Yongyue" uniqKey="Wei Y" first="Yongyue" last="Wei">Yongyue Wei</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Shen, Hongbing" sort="Shen, Hongbing" uniqKey="Shen H" first="Hongbing" last="Shen">Hongbing Shen</name>
<affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hu, Zhibin" sort="Hu, Zhibin" uniqKey="Hu Z" first="Zhibin" last="Hu">Zhibin Hu</name>
<affiliation wicri:level="1"><nlm:aff id="A61">Nanjing Medical University School of Public Health, Nanjing, China</nlm:aff>
<country xml:lang="fr">République populaire de Chine</country>
<wicri:regionArea>Nanjing Medical University School of Public Health, Nanjing</wicri:regionArea>
<wicri:noRegion>Nanjing</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shu, Xiao Ou" sort="Shu, Xiao Ou" uniqKey="Shu X" first="Xiao-Ou" last="Shu">Xiao-Ou Shu</name>
<affiliation wicri:level="1"><nlm:aff id="A59">Vanderbilt University, Nashville, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Vanderbilt University, Nashville</wicri:regionArea>
<wicri:noRegion>Nashville</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Shiraishi, Kouya" sort="Shiraishi, Kouya" uniqKey="Shiraishi K" first="Kouya" last="Shiraishi">Kouya Shiraishi</name>
<affiliation wicri:level="3"><nlm:aff id="A62">Division of Genome Biology, National Cancer Center Research Institute, Tokyo, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Division of Genome Biology, National Cancer Center Research Institute, Tokyo</wicri:regionArea>
<placeName><settlement type="city">Tokyo</settlement>
<region type="région">Région de Kantō</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Takahashi, Atsushi" sort="Takahashi, Atsushi" uniqKey="Takahashi A" first="Atsushi" last="Takahashi">Atsushi Takahashi</name>
<affiliation wicri:level="1"><nlm:aff id="A63">Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama, Japan</nlm:aff>
<country xml:lang="fr">Japon</country>
<wicri:regionArea>Laboratory for Statistical Analysis, RIKEN Center for Integrative Medical Sciences, Yokohama</wicri:regionArea>
<wicri:noRegion>Yokohama</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Bosse, Yohan" sort="Bosse, Yohan" uniqKey="Bosse Y" first="Yohan" last="Bossé">Yohan Bossé</name>
<affiliation wicri:level="1"><nlm:aff id="A64">Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Institut universitaire de cardiologie et de pneumologie de Québec, Department of Molecular Medicine, Laval University, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Obeidat, Ma N" sort="Obeidat, Ma N" uniqKey="Obeidat M" first="Ma N" last="Obeidat">Ma N Obeidat</name>
<affiliation wicri:level="1"><nlm:aff id="A65">University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>University of British Columbia Centre for Heart Lung, Innovation, St. Paul’s Hospital. Vancouver</wicri:regionArea>
<wicri:noRegion>St. Paul’s Hospital. Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Nickle, David" sort="Nickle, David" uniqKey="Nickle D" first="David" last="Nickle">David Nickle</name>
<affiliation wicri:level="2"><nlm:aff id="A66">Merck & Co, MRL, Seattle, Washington, United States</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Merck & Co, MRL, Seattle, Washington</wicri:regionArea>
<placeName><region type="state">Washington (État)</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Timens, Wim" sort="Timens, Wim" uniqKey="Timens W" first="Wim" last="Timens">Wim Timens</name>
<affiliation wicri:level="4"><nlm:aff id="A67">University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen, Netherlands</nlm:aff>
<country xml:lang="fr">Pays-Bas</country>
<wicri:regionArea>University of Groningen, University Medical Center Groningen, GRIAC Research Institute, Groningen</wicri:regionArea>
<placeName><settlement type="city">Groningue</settlement>
<region nuts="2" type="province">Groningue (province)</region>
<settlement type="city">Groningue (ville)</settlement>
</placeName>
<orgName type="university">Université de Groningue</orgName>
</affiliation>
</author>
<author><name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name>
<affiliation wicri:level="3"><nlm:aff id="A68">Dana-Farber Cancer Institute, Boston, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Dana-Farber Cancer Institute, Boston</wicri:regionArea>
<placeName><settlement type="city">Boston</settlement>
<region type="state">Massachusetts</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name>
<affiliation><nlm:aff id="A69">Xiamen University, Xiamen China</nlm:aff>
<wicri:noCountry code="subfield">Xiamen China</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Seminara, Daniela" sort="Seminara, Daniela" uniqKey="Seminara D" first="Daniela" last="Seminara">Daniela Seminara</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<affiliation wicri:level="1"><nlm:aff id="A5">National Cancer Instititute, Bethesda, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>National Cancer Instititute, Bethesda</wicri:regionArea>
<wicri:noRegion>Bethesda</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Peters, Ulrike" sort="Peters, Ulrike" uniqKey="Peters U" first="Ulrike" last="Peters">Ulrike Peters</name>
<affiliation wicri:level="1"><nlm:aff id="A29">Fred Hutchinson Cancer Research Center, Seattle, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Fred Hutchinson Cancer Research Center, Seattle</wicri:regionArea>
<wicri:noRegion>Seattle</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Amos, Christopher I" sort="Amos, Christopher I" uniqKey="Amos C" first="Christopher I." last="Amos">Christopher I. Amos</name>
<affiliation wicri:level="1"><nlm:aff id="A70">Geisel School of Medicine, Dartmouth College, Lebanon</nlm:aff>
<country xml:lang="fr">Liban</country>
<wicri:regionArea>Geisel School of Medicine, Dartmouth College</wicri:regionArea>
<wicri:noRegion>Dartmouth College</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sellers, Thomas A" sort="Sellers, Thomas A" uniqKey="Sellers T" first="Thomas A." last="Sellers">Thomas A. Sellers</name>
<affiliation wicri:level="1"><nlm:aff id="A20">Moffitt Cancer Center, Tampa, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>Moffitt Cancer Center, Tampa</wicri:regionArea>
<wicri:noRegion>Tampa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Easton, Douglas F" sort="Easton, Douglas F" uniqKey="Easton D" first="Douglas F." last="Easton">Douglas F. Easton</name>
<affiliation wicri:level="4"><nlm:aff id="A3">University of Cambridge, Cambridge, UK</nlm:aff>
<country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>University of Cambridge, Cambridge</wicri:regionArea>
<orgName type="university">Université de Cambridge</orgName>
<placeName><settlement type="city">Cambridge</settlement>
<region type="country">Angleterre</region>
<region type="région" nuts="1">Angleterre de l'Est</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
<affiliation><nlm:aff id="A2">Harvard T.H. Chan School of Public Health, Boston MA</nlm:aff>
<wicri:noCountry code="subfield">Boston MA</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
<affiliation wicri:level="4"><nlm:aff id="A6">University of Southern California, Los Angeles, USA</nlm:aff>
<country xml:lang="fr">États-Unis</country>
<wicri:regionArea>University of Southern California, Los Angeles</wicri:regionArea>
<placeName><settlement type="city">Los Angeles</settlement>
<region type="state">Californie</region>
<settlement type="city">Los Angeles</settlement>
</placeName>
<orgName type="university">Université de Californie du Sud</orgName>
</affiliation>
</author>
<author><name sortKey="Hung, Rayjean J" sort="Hung, Rayjean J" uniqKey="Hung R" first="Rayjean J." last="Hung">Rayjean J. Hung</name>
<affiliation wicri:level="1"><nlm:aff id="A1">Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Lunenfeld-Tanenbaum Research Institute of Mount Sinai Hospital, Toronto</wicri:regionArea>
<wicri:noRegion>Toronto</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j">Cancer research</title>
<idno type="ISSN">0008-5472</idno>
<idno type="eISSN">1538-7445</idno>
<imprint><date when="2016">2016</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Breast Neoplasms (genetics)</term>
<term>Colorectal Neoplasms (genetics)</term>
<term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Lung Neoplasms (genetics)</term>
<term>Male</term>
<term>Ovarian Neoplasms (genetics)</term>
<term>Prostatic Neoplasms (genetics)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
<term>Tumeurs colorectales (génétique)</term>
<term>Tumeurs de l'ovaire (génétique)</term>
<term>Tumeurs de la prostate (génétique)</term>
<term>Tumeurs du poumon (génétique)</term>
<term>Tumeurs du sein (génétique)</term>
<term>Étude d'association pangénomique</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Breast Neoplasms</term>
<term>Colorectal Neoplasms</term>
<term>Lung Neoplasms</term>
<term>Ovarian Neoplasms</term>
<term>Prostatic Neoplasms</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Tumeurs colorectales</term>
<term>Tumeurs de l'ovaire</term>
<term>Tumeurs de la prostate</term>
<term>Tumeurs du poumon</term>
<term>Tumeurs du sein</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Female</term>
<term>Genome-Wide Association Study</term>
<term>Genotype</term>
<term>Humans</term>
<term>Male</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Femelle</term>
<term>Génotype</term>
<term>Humains</term>
<term>Mâle</term>
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<front><div type="abstract" xml:lang="en"><p id="P1">Identifying genetic variants with pleiotropic associations can uncover common pathways influencing multiple cancers. We took a two-staged approach to conduct genome-wide association studies for lung, ovary, breast, prostate and colorectal cancer from the GAME-ON/GECCO Network (61,851 cases, 61,820 controls) to identify pleiotropic loci. Findings were replicated in independent association studies (55,789 cases, 330,490 controls). We identified a novel pleiotropic association at 1q22 involving breast and lung squamous cell carcinoma, with eQTL analysis showing an association with <italic>ADAM15/THBS3</italic>
 gene expression in lung. We also identified a known breast cancer locus <italic>CASP8/ALS2CR12</italic>
 associated with prostate cancer, a known cancer locus at CDKN2B-AS1 with different variants associated with lung adenocarcinoma and prostate cancer and confirmed the associations of a breast <italic>BRCA2</italic>
 locus with lung and serous ovarian cancer. This is the largest study to date examining pleiotropy across multiple cancer-associated loci, identifying common mechanisms of cancer development and progression.</p>
</div>
</front>
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<li>Australie</li>
<li>Autriche</li>
<li>Canada</li>
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<li>France</li>
<li>Islande</li>
<li>Japon</li>
<li>Liban</li>
<li>Norvège</li>
<li>Pays-Bas</li>
<li>Royaume-Uni</li>
<li>République populaire de Chine</li>
<li>Singapour</li>
<li>Suède</li>
<li>États-Unis</li>
</country>
<region><li>Angleterre</li>
<li>Angleterre de l'Est</li>
<li>Auvergne-Rhône-Alpes</li>
<li>Bade-Wurtemberg</li>
<li>Basse-Saxe</li>
<li>Bavière</li>
<li>Californie</li>
<li>Connecticut</li>
<li>District de Haute-Bavière</li>
<li>District de Karlsruhe</li>
<li>Grand Londres</li>
<li>Grand Manchester</li>
<li>Groningue (province)</li>
<li>Hollande-Méridionale</li>
<li>Hollande-Septentrionale</li>
<li>Illinois</li>
<li>Massachusetts</li>
<li>Oxfordshire</li>
<li>Pays de la Loire</li>
<li>Pennsylvanie</li>
<li>Rhône-Alpes</li>
<li>Région de Kantō</li>
<li>Svealand</li>
<li>Utah</li>
<li>Victoria (État)</li>
<li>Washington (État)</li>
</region>
<settlement><li>Amsterdam</li>
<li>Boston</li>
<li>Cambridge</li>
<li>Groningue</li>
<li>Groningue (ville)</li>
<li>Göttingen</li>
<li>Heidelberg</li>
<li>Londres</li>
<li>Los Angeles</li>
<li>Lyon</li>
<li>Manchester</li>
<li>Melbourne</li>
<li>Munich</li>
<li>Nantes</li>
<li>Oxford</li>
<li>Pittsburgh</li>
<li>Rotterdam</li>
<li>Stockholm</li>
<li>Tokyo</li>
</settlement>
<orgName><li>Université d'Oxford</li>
<li>Université de Californie du Sud</li>
<li>Université de Cambridge</li>
<li>Université de Groningue</li>
<li>Université de Manchester</li>
<li>Université de Melbourne</li>
<li>Université technique de Munich</li>
</orgName>
</list>
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<name sortKey="Goode, Ellen L" sort="Goode, Ellen L" uniqKey="Goode E" first="Ellen L." last="Goode">Ellen L. Goode</name>
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<name sortKey="Hudson, Thomas J" sort="Hudson, Thomas J" uniqKey="Hudson T" first="Thomas J." last="Hudson">Thomas J. Hudson</name>
<name sortKey="Hunter, David J" sort="Hunter, David J" uniqKey="Hunter D" first="David J." last="Hunter">David J. Hunter</name>
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<name sortKey="Li, Qiyuan" sort="Li, Qiyuan" uniqKey="Li Q" first="Qiyuan" last="Li">Qiyuan Li</name>
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</country>
<country name="Royaume-Uni"><region name="Angleterre"><name sortKey="Pharoah, Paul D" sort="Pharoah, Paul D" uniqKey="Pharoah P" first="Paul D." last="Pharoah">Paul D. Pharoah</name>
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<name sortKey="Muir, Kenneth" sort="Muir, Kenneth" uniqKey="Muir K" first="Kenneth" last="Muir">Kenneth Muir</name>
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<name sortKey="Tyrer, Jonathan P" sort="Tyrer, Jonathan P" uniqKey="Tyrer J" first="Jonathan P." last="Tyrer">Jonathan P. Tyrer</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Chatterjee, Nilanjan" sort="Chatterjee, Nilanjan" uniqKey="Chatterjee N" first="Nilanjan" last="Chatterjee">Nilanjan Chatterjee</name>
</noRegion>
<name sortKey="Ahsan, Habibul" sort="Ahsan, Habibul" uniqKey="Ahsan H" first="Habibul" last="Ahsan">Habibul Ahsan</name>
<name sortKey="Berndt, Sonja I" sort="Berndt, Sonja I" uniqKey="Berndt S" first="Sonja I" last="Berndt">Sonja I. Berndt</name>
<name sortKey="Caporaso, Neil" sort="Caporaso, Neil" uniqKey="Caporaso N" first="Neil" last="Caporaso">Neil Caporaso</name>
<name sortKey="Chan, Andrew T" sort="Chan, Andrew T" uniqKey="Chan A" first="Andrew T." last="Chan">Andrew T. Chan</name>
<name sortKey="Chanock, Stephen J" sort="Chanock, Stephen J" uniqKey="Chanock S" first="Stephen J." last="Chanock">Stephen J. Chanock</name>
<name sortKey="Chen, Y Ann" sort="Chen, Y Ann" uniqKey="Chen Y" first="Y. Ann" last="Chen">Y. Ann Chen</name>
<name sortKey="Figueroa, Jonine" sort="Figueroa, Jonine" uniqKey="Figueroa J" first="Jonine" last="Figueroa">Jonine Figueroa</name>
<name sortKey="Freedman, Matthew L" sort="Freedman, Matthew L" uniqKey="Freedman M" first="Matthew L." last="Freedman">Matthew L. Freedman</name>
<name sortKey="Garcia Closas, Montserrat" sort="Garcia Closas, Montserrat" uniqKey="Garcia Closas M" first="Montserrat" last="Garcia-Closas">Montserrat Garcia-Closas</name>
<name sortKey="Gong, Jian" sort="Gong, Jian" uniqKey="Gong J" first="Jian" last="Gong">Jian Gong</name>
<name sortKey="Gruber, Stephen B" sort="Gruber, Stephen B" uniqKey="Gruber S" first="Stephen B." last="Gruber">Stephen B. Gruber</name>
<name sortKey="Haiman, Christopher A" sort="Haiman, Christopher A" uniqKey="Haiman C" first="Christopher A." last="Haiman">Christopher A. Haiman</name>
<name sortKey="Henderson, Brian E" sort="Henderson, Brian E" uniqKey="Henderson B" first="Brian E." last="Henderson">Brian E. Henderson</name>
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<name sortKey="Brenner, Hermann" sort="Brenner, Hermann" uniqKey="Brenner H" first="Hermann" last="Brenner">Hermann Brenner</name>
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<name sortKey="Hein, Rebecca" sort="Hein, Rebecca" uniqKey="Hein R" first="Rebecca" last="Hein">Rebecca Hein</name>
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<name sortKey="Uitterlinden, Andre G" sort="Uitterlinden, Andre G" uniqKey="Uitterlinden A" first="Andre G." last="Uitterlinden">Andre G. Uitterlinden</name>
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<name sortKey="Sanchez, Maria Jose" sort="Sanchez, Maria Jose" uniqKey="Sanchez M" first="Maria Jose" last="Sanchez">Maria Jose Sanchez</name>
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   |texte=   Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations
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Serveur d'exploration sur les relations entre la France et l'Australie

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations

Cross-cancer genome-wide analysis of lung, ovary, breast, prostate and colorectal cancer reveals novel pleiotropic associations

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	Serveur d'exploration sur les relations entre la France et l'Australie
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